Protein O ‐Mannosylation in Metazoan Organisms
نویسندگان
چکیده
منابع مشابه
Dom34 Links Translation to Protein O-mannosylation
In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits. We found that in the yeast Saccharomyces cerevisiae and the human fungal pathogen Candida albicans, Dom34 interacts genetically with Pmt1, a major isoform of protein O-mannosyltransferase. In C. albicans, lack of Dom34 exacerbated defective phenotypes of pmt1 mutants, while they were ameliorated b...
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Two reports in PNAS by Vester-Christensen et al. (1) and Lommel et al. (2) provide critical new insight into how a unique family of glycans contributes to early embryonic development, brain development, and malignant transformation. Following transfer of mannose (Man) to Ser or Thr by protein Omannosyltransferase (POMT), either POMT1 or POMT2, the O-Man can be further modified with N-acetylgluc...
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The mammalian O-mannosylation pathway for protein post-translational modification is intricately involved in modulating cell-matrix interactions in the musculature and nervous system. Defects in enzymes of this biosynthetic pathway are causative for multiple forms of congenital muscular dystophy. The application of advanced genetic and biochemical technologies has resulted in remarkable progres...
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Protein O-mannosylation is a post-translational modification essential for correct development of mammals. In humans, deficient O-mannosylation results in severe congenital muscular dystrophies often associated with impaired brain and eye development. Although various O-mannosylated proteins have been identified in the recent years, the distribution of O-mannosyl glycans in the mammalian brain ...
متن کاملProtein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.
In recent years protein O-mannosylation has become a focus of attention as a pathomechanism underlying severe congenital muscular dystrophies associated with neuronal migration defects. A key feature of these disorders is the lack of O-mannosyl glycans on α-dystroglycan, resulting in abnormal basement membrane formation. Additional functions of O-mannosylation are still largely unknown. Here, w...
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ژورنال
عنوان ژورنال: Current Protocols in Protein Science
سال: 2014
ISSN: 1934-3655,1934-3663
DOI: 10.1002/0471140864.ps1212s75